Interactions between a poorly soluble cationic drug and sodium …

Semantic Scholar extracted view of "Interactions between a poorly soluble cationic drug and sodium dodecyl sulfate in dissolution medium and their impact on in vitro dissolution behavior." ... Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti ...

Double controlled release of highly insoluble cilostazol …

Section snippets Materials. Cilostazol (CIL) was obtained from Chemagis Co. Ltd. (Ramat Hovav, Israel). The reference tablet, Pletaal ®, was purchased from Otsuka Pharmaceutical Co. Ltd. (Osaka, Japan).Kollidon ® 30 (PVP) was donated from BASF (Seoul, Korea). Sodium lauryl sulfate (SLS) was purchased from Miwon Commercial …

chemical structures of cilostazol (A), cilostazol mesylate …

Naser A. Alkenan. Han-Gon Choi. Cilostazol (CLZ) is an antiplatelet agent with limited solubility (∼6 μg/ml at 25 °C), poor absorption and low oral bioavailability. In this study, solid lipid ...

Pletal (cilostazol) dosing, indications, interactions, adverse …

aspirin/citric acid/sodium bicarbonate. aspirin/citric acid/sodium bicarbonate, cilostazol. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or antiplatelet agents are common for patients with cardiovascular disease; monitor closely ...

Cilostazol (Oral Route) Description and Brand Names

It is used to reduce leg pain caused by poor circulation (intermittent claudication). Cilostazol makes it possible to walk farther before having to rest because of leg pain. This medicine works by keeping blood …

Top-down production of drug nanocrystals

In addition, the performance of the polymeric stabilizers in combination with the ionic surfactants sodium lauryl sulfate and benzethonium chloride (added 1 wt% relative to the polymer weight) was investigated. For the polymeric stabilizers alone, they interpreted the poor results obtained for PEG as a result of the lack of hydrophobic units …

Double controlled release of highly insoluble cilostazol …

Commercially available cilostazol (CIL) tablet releases drug immediately and is given twice a day as an antiplatelet and vasodilatory agent. ... (HPMC) and a pH-dependent polymer (carbomer) assisted with anionic surfactant (sodium lauryl sulfate, SLS). The release profiles of the DCRT were varied according to the ratio of the two …

Cilostazol (Oral Route) Proper Use

For oral dosage form (tablets): For treatment of peripheral vascular disease (circulation problems): Adults—100 milligrams (mg) two times a day, taken at least 30 minutes before or 2 hours after breakfast and dinner. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by a doctor.

Role of Surfactant Micellization for Enhanced Dissolution of …

This study aimed to investigate the role of micellization of sodium lauryl sulfate (SLS) in poloxamer 407 (POX)-based solid dispersions (POX-based SDs) using the anti-solvent method in enhancing the dissolution rate of practically water …

(PDF) Hydrophilic sugars for enhancing dissolution rate of cilostazol …

dissolution media recommended by FDA for cilostazol (0.3% w/v sodium lauryl sulphate in . distilled water). Th e dissolution medium was maintained at 37 ± 1 °C with the pa ddle .

Human and Environmental Toxicity of Sodium Lauryl Sulfate …

Another carcinogenic by-product, 1,4-dioxane, is falsely associated with SLS. 32 1,4-dioxane is categorized as possibly carcinogenic to humans by IARC, 34 and the potential for some surfactants – like sodium laureth sulfate (also called sodium lauryl ether sulfate or SLES) – to be contaminated with 1,4-dioxane during the ethoxylation ...

What Is Sodium Lauryl Sulfate, and What Are Its Uses?

Sodium lauryl sulfate is a surfactant used in most personal care products, soaps, commercial cleaners, and even in food. Learn more about what it is, why it is used, and if it is safe to use it.

Sodium Lauryl Sulfate for Skin: The Complete …

Sodium lauryl sulfate (aka SLS) is a surfactant that has many different functions, but it acts as a cleansing agent in skincare. It's a type of sulfate and is derived from coconut oil, palm kernel oil, or …

Sodium Lauryl Sulfate (SLS)

SLS has been an ingredient in shampoos since the 1930s. It works as a surfactant, trapping oil and dirt in hair so it can be rinsed away with water. SLS can help create a rich lather in products like body and hand wash, facial cleansers and bubble bath. SLS also helps create the ing action in toothpaste and helps remove food particles …

Cilostazol Solubilization and Stabilization Using a Polymer …

Cilostazol (CLT) is a phosphodiesterase inhibitor that improves treadmill walking performance by approximately 25–40% in people with symptomatic peripheral arterial disease . ... and surface-attached solid dispersions with polyvinylpyrrolidone K30® and sodium lauryl sulfate (SLS), have been developed .

Formulation of cilostazol spherical agglomerates by crystallo …

Cilostazol agglomerates were prepared using various polymers with varying concentration of hydroxypropyl methylcellulose E 50 (HPMC E50), polyvinyl pyrrolidone K30 (PVP K30), and polyethylene glycol 6000. ... (0.3% sodium lauryl sulfate [SLS] solution) and distilled water until saturation. The saturated solution was placed in orbital shaker ...

Reprecipitation of poorly water-soluble cilostazol crystals …

Mannitol and lactose monohydrate were provided by DFE Pharma (Japan). Sodium lauryl sulfate (SLS) and sodium oleate were obtained from Sigma-Aldrich (USA). Microcrystalline cellulose ... Cilostazol (CLZ) is an antiplatelet agent with limited solubility (∼6 μg/ml at 25 °C), poor absorption and low oral bioavailability. In this study, solid ...

Reprecipitation of poorly water-soluble cilostazol crystals …

The aim of this new work was to improve the dissolution rate of poorly water-soluble cilostazol (CLT) by adsorbing dissolved drug molecules onto the surface of undissolved carriers via reprecipitation and deposition process as the solvent (methylene chloride) was evaporated. ... containing 0.2% sodium lauryl sulfate than the control …

Cilostazol: Uses, Side Effects, Dosage & Reviews

cilostazol. Used for Peripheral Artery Disease. Cilostazol is used to ease pain, numbness, and tingling in the legs of people who have poor blood flow due to a condition called intermittent claudication. It improves your ability to walk longer distances without discomfort or pain. Reviewed by: Sean Moshrefi, PharmD.

Solubilization of drugs using sodium lauryl sulfate: …

Semantic Scholar extracted view of "Solubilization of drugs using sodium lauryl sulfate: Experimental data and modeling" by M. Alizadeh et al. Skip to search form ... Role of Surfactant Micellization for Enhanced Dissolution of Poorly Water-Soluble Cilostazol Using Poloxamer 407-Based Solid Dispersion via the Anti-Solvent Method. …

Cilostazol

Cilostazol tablets for oral administration are available in 50 mg and 100 mg round, white debossed tablets. Each tablet, in addition to the active ingredient, contains the following inactive ingredients: carboxymethylcellulose calcium, pregelantized starch, hypromellose, magnesium stearate, microcrystalline cellulose, and sodium lauryl sulfate.

Drug-Excipient Compatibility Testing of Cilostazol Using …

Cilostazol possesses pharmacological restrictions, such as its absorption being limited by its ... magnesium stearate, isopropyl alcohol, sodium lauryl sulfate, polyvinylpyrrolidone K30, and corn starch were subjected to Fourier-transform infrared spectroscopy (FTIR) equipped with an ...

Cilostazol

Cilostazol is a quinolone derivative primarily used to treat intermittent claudication due to peripheral vascular disease, …

(PDF) Impact of the manufacturing technique on the …

Cilostazol was selected as poorly-soluble model drug to investigate the impact of the manufacturing method on the excipient functionality of PEG4000 at various levels. ... sodium lauryl sulfate ...

Dissolution profiles of cilostazol-free base ( ), cilostazol …

As shown Figure 3 A, cilostazol-free base released 25.4%±3.56% of drug in HCl buffer (pH 1.2) at 6 hours, while cilostazol mesylate and cilostazol besylate showed higher levels of cilostazol ...

What is Sodium Lauryl Sulfate and Is It Safe?

Sodium Lauryl Sulfate: Just The Facts. There's a lot to know when it comes to SLS. Here's a little breakdown of sodium lauryl sulfate and its connection to toothpaste. SLS is a cleaning agent and surfactant found in many consumer products, according to Chemical Safety Facts; Because of it's cleaning power, SLS is prevalent in toothpaste

Cilostazol Oral: Uses, Side Effects, Interactions, Pictures

Cilostazol can decrease the muscle pain / cramps that occur during exercise /walking. Claudication pain is caused by too little oxygen getting to the muscles. Cilostazol can increase blood flow ...

(PDF) Drug-Excipient Compatibility Testing of Cilostazol

Cilostazol + sodium . lauryl sulfate. 157.94 °C 2.4454. Cilostazol + polyvinylpyrrolidone K30 (PVP K30) 168.64 °C 4.1091. ... Croscarmellose sodium (CCS) and sodium lauryl sulfate (SLS) were ...